List of communications


Elucidating the role of SOX3 gene in glioblastoma multiforme cell lines

Jelena Marjanovic Vicentic, Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia; Danijela Drakulic, Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia; Vladanka Topalovic, Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia; Marija Mojsin, Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia; Jovana Despotovic, Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia; Danijela Stanisavljevic, Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia; Jelena Popovic, Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia; Isidora Petrovic, Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia; Milena Stevanovic, Institute of molecular genetics and genetic engineering, University of Belgrade, Serbia


Glioblastoma multiforme (GBM) is one of the most aggressive and deadly forms of cancer despite intensive therapeutic strategies. Glioblastoma cells express several genes typical for normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self-renewal of stem cells. SOX2, together with SOX1 and SOX3 genes, belongs to a SOXB1 subfamily of genes which encode a family of transcription factors with important roles in embryonic development and carcinogenesis. While function of SOX2 was well studied in gliomas, the role of SOX1 and SOX3 in GBM has not yet been determined.
We have investigated the effects of elevated SOX3 expression on proliferation, viability, cell cycle and migration of human glioblastoma multiforme cell lines, U251 and U87. We have detected SOX3 expression in these cell lines where it acts as a transcription activator. Additionally, overexpression of SOX3 gene increased proliferation and viability of U251 and U87 cells with no effect on cell cycle distribution. Up-regulation of this gene has altered migration of glioblastoma multiforme cell lines. The results obtained in this study implicate potential function of SOX3 in glioblastoma multiforme cell lines.

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