A mathematical model of low grade gliomas treated with temozolomide and its therapeutical implications.
M.U. Bogdańska, University of Warsaw, M. Bodnar, University of Warsaw, J. Belmonte-Beitia, Universidad de Castilla-La Mancha, M. Murek, Bern University Hospital, P. Schucht, Bern University Hospital,
J. Beck, Bern University Hospital, V. M. Pérez-García, Universidad de Castilla-La Mancha
We use mathematical framework to describe growth of low grade gliomas (LGGs) and their response to chemotherapy (temozolomide, TMZ).
Results agrees with data on patients diagnosed with LGGs and treated with TMZ at Bern University Hospital. The model predicts, and our clinical data confirms, that the speed of response to chemotherapy is related to both proliferative potency of tumour and its resistance to therapy. Moreover, we provide estimated formula for time of tumour response to therapy, which can be used as a measure of tumour aggressiveness. Finally, we suggest chemotherapy fractionation scheme that might be therapeutically useful to predict the tumour growth and further prognosis.