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Effects of Anti-Angiogenesis on Glioblastoma Growth and Migration: Model to Clinical Predictions

Olivier Saut, INRIA Monc ; Elizabeth Scribner, Dept. Math. , UAB ; Thierry Colin, INRIA Monc ; Hassan M. Fathallah-Shaykh, Dept. Math. & Neurology, UAB


Glioblastoma multiforme (GBM) is a brain tumor that causes significant neurological morbidity and has short survival times. Brain invasion by GBM is associated with poor prognosis. Recent clinical trials of anti-angiogenic drugs in newly-diagnosed GBM found no beneficial effects on overall survival times; however, the baseline health-related quality of life and performance status were maintained longer in the treated group. We have constructed a clinical-scale model of GBM whose predictions uncover a new pattern of recurrence in 11/70 treated patients. The findings support an exception to the Folkman hypothesis: GBM grows in the absence of angiogenesis by a cycle of proliferation and brain invasion that expands necrosis. Furthermore, necrosis is positively correlated with brain invasion in 26 newly-diagnosed GBM. The unintuitive results explain the unusual clinical effects of the drug and suggest new hypotheses on the dynamic clinical effects of migration by advectiont, a mechanism of hypoxia-driven brain invasion.

Format: Oral communication

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